Cytokine Production as a Putative Biological Mechanism Underlying Stress Sensitization in High Combat Exposed Soldiers

Type
Summary

814 Dutch military personnel participated in a study testing how combat exposed Soldiers respond to post-deployment stressful life events, including immune activation measured by cytokines. There was a three way interaction effect of combat stress exposure, cytokine production, and post-deployment stressful life events on change in PTSD symptoms over the first two years after return from deployment.

Citation
Smid, G. E., van Zuiden, M., Geuze, E., Kavelaars, A., Heijnen, C. J., & Vermetten, E. (2015). Cytokine production as a putative biological mechanism underlying stress sensitization in high combat exposed soldiers. Psychoneuroendocrinology, 51, 534-546. doi:10.1016/j.psyneuen.2014.07.010